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Vaginal adenosis precedes the development of which of the following? Condyloma acuminatum Cervical carcinoma @Clear cell carcinoma Carcinoma of the endometrium Squamous carcinoma of the vagina # 5 A 25-year-old woman being evaluated for infertility is found to have an abnormal ridge of red, moist granules located in the upper third of her vagin. Pertinent medical history is that her mother was treated with diethylstilbestrol (DES) during her pregnancy. A biopsy from the abnormal vaginal ridge reveals the presence of benign glands underneath stratified squamous epithelium. Which of the following is the most serious long-term complication of this abnormality? @Clear cell carcinoma Condyloma acuminatum Extramammary Paget's disease Multiple papillary hidradenomas Verrucous carcinoma # 6 A 30-year-old woman, with a history of a chronic endocervicitis, passed routine inspection at the gynecologist with no complaints. A histological investigation of a biopsy, taken from the pars vaginalis neck of the uteri, revealed the high cylindrical epithelium, secreting mucus and branched out glands underneath. What is the most likely diagnose? @Endocervicosis Squamous metaplasia Glandular metaplasia Leukoplakia Erythroplakia # 7 A histological investigation of curettage of the cervical canal of the uteri revealed a prismatic epithelium and a significant amount of gland-like structures. They developed from the prismatic epithelium cambial elements, originated from the neck of a uterus. What is the most likely diagnose? @Proliferative endocervicosis Simple endocervicosis Endocervicosis, stage of healing Cervical adenomatosis Cervical polyps # 8 A gynecologic investigation of the 36-year-old woman revealed bright red brilliant maculae on a uterus neck. They bleed easily at a touch. Biopsy investigation showed that a tissue sample was covered by a cylindrical epithelium with papillary growths. There was also a growth of glands within the thickness of a uterus neck tissue. What pathology of a uterus neck was diagnosed? @Pseudoerosion Cervical erosion Endocervicitis Glandular hyperplasia Leukoplakia # 9 Which of the following describes multiple small mucinous cysts of the endocervix that result from blockage of the endocervical glands by overlying squamous metaplastic epithelium? Bartholin's cysts Chocolate cysts Follicular cysts Gartner's duct cysts @Nabothian cysts # 10 The pathologist has found out in histological examination of a remote uterus a lot of glandular formations with syngl cycts in myometrium., endometrium had usual structure. Described changes are characteristic for @Endometriosis. Glandular hyperplasia of endometrium. Adenocarcinoma of uterus Adenomatosis of a mucosa of a uterus Leyomyosarcoma of uterus. # 11 A 25-year-old woman presents to your office for workup of infertil¬ity. In giving a history she describes severe pain during menses, and she also tells you that in the past another doctor told her that she had "choco¬late in her cysts." Which of the following abnormalities is most likely to be present in this patient? Metastalic ovarian cancer @Endometriosis Acute pelvic inflammatory disease Adenomyosis A posteriorly located subserosal uterine leiomyoma # 12 All the following endometrial changes are consistent with secretory endometrium EXCEPT basal cytoplasmic vacuoles secretions within glandular lumen predecidual refction within stroma neutrophil infiltrate @plasma cell infiltrate # 13 A 24-year-old woman presents with a 2-year history of infertility. An endometrial biopsy is obtained approximately 5 to 6 days after the predicted time ofovulation. This biopsy specimen reveals secretory endometrium, but there is a significant difference (asynchrony) between the estimated chrono¬logic menstrual date and the estimated histologic menstrual datNo prolif-erative endometrium is seen. Which of the following is the most likely diagnosis? Anovulatory cycle (no corpus luteum formed) @Inadequate luteal phase (decreased functioning of the corpus luteum) Irregular shedding (prolonged functioning of the corpus luteum) Normal endometrium during the follicular phase of the cycle (no corpus luteum formed) Normal endometrium during the luteal phase of the cycle (normal corpus luteum) # 14 A 23-year-old woman presents with urinary frequency and abnormal uterine bleeding. A careful medical history finds that her abnormal men¬strual bleeding is characterized by excessive bleeding at irregular intervals. A pelvic examination finds a single mass in the anterior wall of the uterus, this being confirmed by ultrasonography. Which one of the following clin¬ical terms best describes the abnormal uterine bleeding in this woman? Amenorrhea Dysmenorrhea @Menometrorrhagia Oligomenorrhea Polymenorrhea # 15 A 50-year-old woman presents with fatigue, insomnia, hot flashes, night sweats, and absence of menses for the last 5 months (secondary amenorrhea). Her urine hCG test is negativLaboratory tests reveal decreased serum estrogen and increased serum FSH and LH levels. Which of the following is the most likely cause of this individual's clinical signs and symptoms? 17-hydroxylase deficiency of the adrenal cortex Prolaccin-secreting tumor of the anterior pituitary Gonadotropin-releasing hormone-secreting tumor of the hypothalamus @Menopause Menarche # 16 Histological exam of the uterine mucosa reveals anfractuous glands (sew- and bottlescrew-like), elongated overgrowths of stroma with proliferation of its cells. What is your diagnosis? Placental polyp Acute endometritis Leiomyoma Molar pregnancy @Glandular hyperplasia of endometrium # 17 A microscopic investigation of an endometrium revealed coiled extended glands with 'saw' and a 'spin-like' pattern. A stromal proliferation with hyperplasia of its cells was also determined. What is the most likely diagnosis? @Glandular hyperplasia of endometrium Acute endometritis Leiomyoma Hydatidiform mole Placental polyp # 18 A 45-year-old woman with a medical history of a menstrual cycle disturbance had curettage of the uterine cavity to obtain endometrial tissue for histopathologic analysis. Microscopic investigation revealed the increased quantity of the endometrial glands, their form irregularity. Some of glands were dilated or had a saw-like pattern. What is the most likely diagnosis? @Cystic glandular hyperplasia of endometrium Placental polyp Atypical hyperplasia of endometrium Glandular polyp of endometrium Endometrial adenocarcinoma # 19 A 42-year-old woman presented with dysfunctional uterine bleeding. A histological investigation of a curettage material revealed increased quantity of coiled glands and their cystic dilation. What is the most likely diagnosis? @Cystic glandular hyperplasia Atrophy Metaplasia Displasia Hypertrophic vegetations # 20 Cystic hyperplasia of the endometrium is associated with all the following EXCEPT occurence at or just before menopause increased estrogen administration or production excessive uterine bleeding @secretory cells lining the cystically bilated glands functioning granulosa-theca cell tumors # 21 A 60-year-old postmenopausal woman presents with the new onset of uterine bleeding. An endometrial biopsy is diagnosed as atypical hyper-plasi. Which of the following histologic changes is most characteristic of this abnormality? @Crowding of endometrial glands with budding and epithelial atypia Lymphatic invasion by interlacing bundles of atypical spindle-shaped cells Menstrual-type endometrial glands with focal atypical cystic dilatation Secretory-type endometrial glands with hyperplasia of atypical polygonal cells clear cytoplasm Stromal invasion by malignant glands with focal areas of atypical squamous dif¬ferentiation # 22 A 52-year-old woman, with a medical history of the menstrual cycle disturbances and hemorrhages, had curettage of the uterine cavity. Histological investigation revealed the increased quantity of the endometrial glands. Many glands had a morphological pattern of a proliferation phase, clumped together and had intraglandular papillary protrusions. Some glandular cells exhibited the signs of nuclear and cytoplasm polymorphism. What is the most likely diagnosis? @Atypical hyperplasia of endometrium Cystic glandular hyperplasia of endometrium Glandular hyperplasia of endometrium Glandular polyp of endometrium Adenocarcinoma of endometrium # 23 A 46-year-old woman undergoes an abdominal hysterectomy for a "fibroid" uterus. The surgeon requests a frozen section on the tumor, which is deferred because of the lesion's degree of cellularity. Which of the fol¬lowing criteria will be used by the pathologist in determining behignancy versus malignancy in permanent sections? @Milotic rate Cell pleomorphism Cell necrosis Nucleus-io-cytoplasm ratio Tumor size # 24 Prolonged unopposed estrogen stimulation in an adult woman increases the risk of development of endometrial hyperplasia and subse¬quent carcinomWhich of the following is the most common histologic appearance for this type of cancer? @Adenocarcinoma Clear cell carcinoma Small-cell carcinoma Squamous cell carcinoma Transitional cell carcinoma # 25 A 23-year-old woman presents to her gynecologist for a routine physical examination that includes a Pap smear. Her sexual history includes many sexual partners beginning at an early age, but she has never been pregnant. Physical examination is unremarkabl. The Pap smear returns as abnormal with the presence of atypical squamous epithelial cells of undetermined significance (ASCUS). She returns for a 6-month follow-up and a repeal pelvic exam is performe. Her cervix is painted with iodine and an area near the cervical os is present that does not stain with iodine. This area is flat and not papillary. Several biopsies are obtained from this pale area, and a representative histologic section shows poilocytosis, which is most character¬istic of infection with which one of the following organisms? Cytomegalovirus Epstein-Barr virus Herpes simplex virus @Human papillomavirus ParvovirusBlO # 26 An 18-year-old woman presents with amenorrhea and is found to, have normal secondary sex characteristics and normal-appearing external genirali. Her first menstrual period was at age 13, and her cycle has been unremarkable until now. She states that her last menstrual period was 8 weeks prior to this visit. A urine test for hCG is positive. Which of the following is the most likely diagnosis? Ectopic pregnancy @Intrauterine pregnancy Stein-Leventhal syndrome Turner's syndrome Weight loss syndrome # 27 A 24-year-old woman delivers a normal 8-lb baby boy at 40 weeks of gestation. She has no history of drug abuse, and her pregnancy was unre-markablExamination had revealed the placenta to be located normally, but following delivery the woman fails to deliver the placenta and subse¬quently develops massive postpartum hemorrhage and shock. Emergency surgery is performed to stop the bleeding. Which of the following is the most likely cause of her postpartum bleeding? An abruptio placenta A placenta previa @A placenta accreta A hydatidiform mole A chorioncarcinoma # 28 A 29-year-old woman presented to maternity department with termination of pregnancy at 20 weeks of gestation. The fetus and fetal membranes were delivered with some blood clots. Histological investigation revealed fetal membranes, chorion villi and decidual tissue. Name -the described pathology of pregnancy. @Spontaneous complete abortion Premature birth Hydatidiform mole Invasive hydatidiform mole Artificial abortion # 29 A 26-year-old woman acutely develops lower abdominal pain arid vaginal bleeding. While in the bathroom she passes a cast of tissue com¬posed of clot material and then collapses. She is brought to the hospital, where a physical examination reveals a soft, tender mass in right adnexa and pouch of Douglas. Histologic examination of the tissue passed in the bathroom reveals tilood clots and decidualized tissuNo chorionic villi or trophoblastic tissues are present. Which of the following conditions is most likely present in this individual? Aborted intrauterine pregnancy Complete hydatidifbrm mole @Ectopic pregnancy Endometrial hyperplasia Partial hydatidiform mole # 30 A 23-year-old woman presents with her menstrual cycle disorder went trough a transvaginal puncture of Douglas’ cul-de-sac resulted in aspiration of blood and some other material. A microscopic investigation of the puncture fluid revealed blood, some decidual cells and chorion villi. What is the most likely diagnosis? @Ectopic tubal pregnancy Salpingitis Rupture of Fallopian tube Hydatidiform mole Carcinoma uteri # 31 A 35-year-old woman had an operation of uterine tube removal at gynecology department. A histological research of a tube's wall reveled chorion villi and decidual cells. What is the most likely diagnosis? @Tubal pregnancy Placental polyp Choriocarcinoma Paper-doll fetus Lithopedion # 32 A young woman presented to the hospital with an acute pain. Her uterine tube was removed at gynecology department. Macroscopic investigation of a tube revealed its local dilation at the middle third and blood clots accumulations within the lumen. A histological research showed chorion villi, surrounded by areas of erythrocytes with some leucocytes. What is the most likely diagnosis? @Tubal pregnancy Acute purulent salpingitis Hemorrhage in tube of the uteri Hemorrhagic salpingitis Tuberculous salpingitis # 33 A 39 y.o. woman went through an operation in course of which surgeons removed her uterine tube that was enlarged and a part of an ovary with a big cyst. Histological examination of a tube wall revealed decidual cells, chorion villi. What was the most probable diagnosis made after examination of the uterine tube? Lithopedion Choriocarcinoma Papyraceous fetus @Tubal pregnancy Placental polyp # 34 At the operation of a 39-year-old woman were removed an enlarged in size uterine tube and a part of ovary with a big cyst. Histological exam of the mucous membrane of the tube wall revealed decidual cells and villi of chorion. What is the most possible diagnosis? Choriocarcinoma Placental polyp @Tubal pregnancy Papyraceous fetus Lithopedion # 35 A 25-year-old woman with a medical history of recent childbirth presented to gynecology department with metrorrhagia. The histological investigation of a curettage material revealed a pathologic growth, consisted of fibrin clots, chorion villi and decidual tissue, undergoing organization. What is the most likely diagnosis? @Placental polyp Glandular hyperplasia of the endometrium Hydatidiform mole Choriocarcinoma Endometritis # 36 A woman harboring endometrial adenocarcinoma nearly always has antecedent obesity diabetes millitus @endometrial polyps endometrial hyperplasia systemic hypertention # 37 A 25-year-old woma in her 15th week of pregnancy presented with uterine bleeding and passage of a small amount of watery fluid and tissue. She is found to have a uterus that is mach larger than estimated by her gestetional dates. Her uterus is found to be filled with cystic, avascular, grapelike structures that do not penetrate the uterine wall. No fetal parts are found. The most likely diagnosis for this adnormality is partial hydatidiform mole @complete hydatidiform mole invasive mole placental site trophoblastic tumor chorioncarcinoma # 38 A patient had an operation relatively uterine tumour. Macroscopically: a spongy mottled nodule in the myometrium. Histological exam reveals giant bright epithelial cells, among which many dark polymorphous ones are noted. Stroma is absent, vessels look like lumens covered with tumour cells. Multiple haemorrhages are detected, too. How can we term the determined tumour? @Chorionepithelioma Destructive (malignant) molar pregnancy Adenocarcinoma Cavernous hemangioma Medullary cancer # 39 6 months after labour a woman had uterine hemorrhag E. Gynaecological examination of uterine cavity revealed a dark-red tissue with multiple cavities resembling of a "sponge". Microscopic examination of a tumour revealed in blood lacunas atypic light epithelial Langhans cells and giant cells of syncytiotrophoblast. What tumour is it? Fibromyoma Squamous cell nonkeratinous carcinoma @Chorioepithelioma Adenocarcinoma Cystic mole # 40 A 26-year-old woman in the third trimester of her first pregnancy develops persistent headaches and swelling of her legs and facEarly dur¬ing her pregnancy a physical examination was unremarkable; however, now her blood pressure is 170/105 mmHg and urinalysis reveals slight proteinuriWhich of the following is the most likely diagnosis? Eclampsia Gestational trophoblastic disease Nephritic syndrome Nephrotic syndrome @Preeclampsia # 41 A- post-mortem of a pregnant woman revealed a brain edema, hemorrhagic pneumonia, motley liver with a hemorrhage. Microscopic study showed disseminated blood clotting of vessels, plural fine necroses and hemorrhages in internal organs. In addition, in kidneys there were found cortical necroses and a fibrinoid necrosis of a tubules epithelium within a nephron. |