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@ Lipoma. Fibroma. Hygroma. Papilloma. Hemangioma. # 17 From the organism of the 65-year old woman tumor-like body 1,0x1,0x0,8 cm was removed from the underskin part of the hip. Macroscopically: the body is represented by lipoid tissue inside capsule. Microscopically: different in seize lobuli of lipoid tissue, separated by connective tissue. Name the body: @Lipoma Hybernoma Liposarcoma Fibroma Desmoid # 18 A a 27-year-old woman in excellent health has a routine health maintenance examination. A 2 cm firm, rounded mass is palpable beneath the skin of the left forearm. She has no difficulty using the arm and there is no associated pain with the mass, either in movement or on palpation. The overlying skin appears normal. The mass does not change in size over the next year. Which of the following neoplasms is she most likely to have? @Lipoma Metastatic carcinoma Melanoma Rhabdomyosarcoma Leiomyoma # 19 A 50-year-old man has felt vague abdominal discomfort within past 4 months. Physical examination revealed no lymphadenopathy, and no abdominal masses or organomegaly at palpation. Bowel sounds are heard. An abdominal CT scan shows a 20 cm retroperitoneal soft tissue mass obscuring the left psoas muscle. A stool specimen tested for occult blood is negative. Which of the following neoplasms is this man most likely to have? Adenocarcinoma Lymphoma Melanoma @Lipoma Hamartoma # 20 A 35-year-old man presents with the new onset of a “bulge” in his left inguinal area. After performing a physical examination, you diagnose the bulge to be an inguinal hernia. You refer the patient to a surgeon, who repairs the hernia and sends the resected hernia sac to the pathology laboratory along with some adipose tissue, which he calls a “lipoma of the cord”. The pathology resident examines the tissue grossly and microscopically and decides that it is not a neoplastic lipoma, but instead is nonneoplastic normal adipose tissue. Which one of the following features should be present to make the diagnosis of lipoma rather than normal adipose tissue? Anaplasia Fibrous capsule Numerous mitoses @Prominent nucleoli Uniform population of cells # 21 A 75-year-old patient was removed a tumour (16 x 8 x 6cm) from extraabdominal cellular tissue. Microscopically were detected the anaplastic fatty cells with the signs of cellular atypism and polymorphism. Giant deformed cells with the drops of oil in the cytoplasm could be also seen. What is the most possible diagnosis? Myosarcoma Lipoma Fibrosarcoma @Liposarcoma Mesotelioma # 22 A 14x6x5 cm neoplasm excised from a retroperitoneum of a 66-year-old woman at surgery department. Microscopic investigation revealed atypical anaplastic cells, which contained round cytoplasmic vacuoles of lipid that scallop the nucleus. The majority of cells were pleomorphic, some of them were round with chromosomal abnormalities. What is the most likely diagnosis? @Liposarcoma Lipoma Myosarcoma Fibrosarcoma Mesothelioma # 23 A 50-year-old man have felt vague abdominal discomfort for the past 4 months. A stool specimen tested for occult blood is negative. He has no lymphadenopathy, and no abdominal masses or organomegaly can be palpated. Bowel sounds are present. An abdominal CT scan shows a 20-cm retroperitoneal soft tissue mass obscuring the left psoas muscle. This neoplasm is most likely to be a (n): Melanoma Hamartoma Adenocarcinoma Lymphoma @Liposarcoma # 24 The atypical rhabdomyoblasts illustrated in the photomicrograph below may be seen in all following lesions EXCEPT Sarcoma botryoides @Myositis ossificans Mixed heterologous mьllerian tumor of the uterus Adult pleomorphic rhabdomyosarcoma Embryonal rhabdomyosarcoma # 25 A 52-year-old man presents with symptoms of gastric pain after eating. During work-up a 3-cm mass is found in the wall of the stomach. This mass is resected and histologic examination reveals a tumor composed of cells having elongated, spindle-shaped nuclei. The tumor does not connect to the overlying epithelium and is found only in the wall of the stomach. Which of the following is the cell of origin of this tumor? Adipocyte Endothelial cell Glandular epithelial cell @Smooth-muscle cell Squamous epithelial cell # 26 During a histological research of an uterus: under mucous membrane there are numerous round nodes, separated from adjacent tissues. Microscopically the tumour is made of bunches of non-stratified muscles with tissue atypism. What is the diagnosis? Chorionepithelioma Cancer of uterus Fibromyoma @Leiomyoma Leiomyosarcoma # 27 A physical examination of 47-year-old woman of gynecology department revealed that her uterus contained dicrete, firm, white nodules. Histological examination excised lesion demonstrated a tissue atypia of a sample. It presented well-defferentiated mature cells of smooth muscules. What is the most likely diagnosis? @Leiomyoma. Carcinoma of the uterus. Fibromyoma. Chorionepithelioma. Leiomyosarcoma # 28 A 35-year-old woman had a firm nodule palpable on the dome of the uterus six years ago recorded on routine physical examination. The nodule has slowly increased in size and is now appears to be about twice the size it was when first discovered. She remains asymptomatic. Which of the following neoplasms is she most likely to @Leiomyoma Adenocarcinoma Leiomyosarcoma Hematoma Metastasis # 29 A removed at the operation uterus was delivered for the histological examination. Multiple nodules of a round form, neatly isolated from surrounding tissue, were revealed under the mucous membrane. Microscopically the tumour consists of fascicles of nonstriated muscles with tissue atypism. What is your diagnosis? @Leiomyoma Uterine cancer Fibromyoma Chorionepithelioma Leiomyosarcoma # 30 An epidemiologic study is performed to determine risk factors for development of malignant neoplasms. A statistical analysis of pre-existing medical conditions is done. Some pre-existing conditions are observed to precede development of malignant neoplasms, while others do not. Which of the following conditions is most likely to be statistically unrelated to subsequent malignancy? @Uterine leiomyomas Endometrial atypical hyperplasia Chronic alcoholism with hepatic cirrhosis Cervical squamous dysplasia Chronic ulcerative colitis # 31 A macroscopical investigation of operatively removed uterus revealed a tumour with a soft consistence, hemorrhages and necroses. The tumor cut surface reminds ' the fish meat'. Histological research has found an expressed cellular and tissue atypia; there were cells with pathological mitoses figures. What is the most likely diagnosis? @Sarcoma. Adenocarcinoma. Angioma. Fibroma. Lipoma. # 32 Macroscopically the uterine cancer (after operation material) is of soft consistence, with hemorrhages and areas of focal necrosis. It looks like fish meat when incised. At the histological examination the signs of cell and tissue atypism are traced. The cells with pathological mitoses can be also seen. What is your diagnosis? Adenocarcinoma @Sarcoma Angioma Fibroma Lipoma # 33 A 15-year-old young man presented with a tumorous formation in the central site of his wrist bone. The node grew slowly within last 3 years. A histological research of a removed neoplasm revealed mature chondrocytes without mitoses, which randomly located in chondral lacunas. Cartilages of a capsule had different form and the sizes due to variable quantity of chondral cells, between which there were basic substance with liquid layers of a connective tissue. What is the most likely diagnosis? @Chondroma Chondroblastoma Chondrosarcoma Teratoma - # 34 All the following statements about chondrosarcoma are true EXCEPT that It is most frequent in middle age or later The peripheral type can arise from enchondroma It is common in the pelvic bones Histologic analysis is of prognostic significance @It is the second most common malignant bone tumor # 35 The most common tumor that involves bone is @A metastatic tumor from an extraosseous site Osteogenic carcinoma Multiple myeloma Chondrosarcoma A giant cell tumor # 36 A 50-year-old patient presented to the doctor with a ball-shaped, dense, motionless neoplasm, 2 cm in diameter, under a skin in the right parietal site of his head. A histological research of a removed neoplasm revealed a chaotic osteal beams pattern with a connective tissue between. What is the most likely diagnosis? @Cancellous osteoma (Osteoma spongiosum) Compact osteoma (Osteoma durum) Osteoporosis Osteomalacia Osteosarcoma # 37 Osteosarcoma (osteogenic sarcoma) has an increased incidence in all the following conditions EXCEPT Paget’s disease Retinoblastoma Fibrous dysplasia @Plasmocytoma Osteochondromatosis # 38 At the young woman in'the area of her distal extremity of a femur the tumor, which quickly grew, is removed. Grossly, it had a motley pattern - from white-sulphur to brown-red color and a quaggy consistence. Microscopical investigation revealed the basic tissue component of a tumor presented with osteal and the ossiform structures covered by atypical osteoblasts, with numerous thin-walled vessels and atypical mitoses figures. Make a diagnosis. @Osteocarcoma Chondroma Osteoma Ewing’s sarcoma Angiosarcoma # 39 A 28-year-old man with a history of an elbow bruise 3 years ago presented with a tumorous growth in the area of an epiphysis of a humeral bone. The formation did not have accurate borders. A histological investigation of biopsy material revealed a considerable quantity of polymorphic cells of osteoblastic type with numerous pathological mitoses. Make the presumable diagnosis. @ Osteosarcoma Chondrosarcoma Osteoid-osteoma Fibrosarcoma Sinovial sarcoma # 40 Characteristics of Ewing’s sarcoma include all the following EXCEPT Primary occurrence prior to age 20 @Primary occurrence in the epiphysis of long bones Onion-skin pattern on x-ray Basophilic cells resembling lymphocytes PAS-positive intracytoplasmic glycogen # 41 An 11-year-old boy presents with an enlarging, painful lesion that involvers medullary cavity of his left femur. X-rays reveals an irregular, destructive lesion that produced an “onion-skin” periosteal reaction. The lesion is resected surgically, and Histologic sections reveal sheets of uniform small, round, “blue” cells. Which of the following is the most likely diagnosis? Chondroblastoma @Ewing’s sarcoma Fibrosarcoma Osteoblatoma Osteogenic sarcoma # 42 A 16-year-old child presented with a painful softish node in his femur diaphysis. The formation grows quickly with destruction of a spongy layer of a bone. Microscopical investigation revealed monomorphic round cells little bit bigger than mature lymphocytes, with jejunely light cytoplasm which contains glycogen. In some zones these cells form pseudo- rosettes with few mitoses. Between cells there are fibrinous membranes. What is the most likely diagnosis? @Ewing's sarcoma Limphoma Rhabdomyosarcoma Neuroblastoma Hemangioma # 43 A 49-year-old man complains of pain in his left thigh for 3 months. On physical examination his thigh is increased in size, compared to the right. A plain film radiograph reveals the presence of a 15 cm solid mass that does not appear to arise from bone, but it does have infiltrative margins. A biopsy of this mass is taken, and on microscopic examination the mass is composed of highly pleomorphic spindle cells. Name tumor? Fibroma Chondroma Osteoma @Osteosarcoma Carcinoma # 44 In an epidemiologic study, "fallout" from nuclear bomb testing and from nuclear power plant disasters is observed to have released radioactive isotopes into the environment. One of these isotopes is found to be strontium-90. It is observed that the strontium-90 in soils goes into the food chain and eventually contaminates milk products. This contamination is most likely to increase the risk for which of the following neoplasms? Kaposi's sarcoma of skin Small cell anaplastic carcinoma of lung @Osteosarcoma Nasopharyngeal carcinoma Endometrial carcinoma # 45 During an examination of a 25-year-old patient: right half of mandible is spindle-shaped and enlarged, thickened, with a smooth surface. A puncture revealed a liquid of brown colour. Histologically: mononuclear cells, presumably osteoblasts, and giant multinuclear cells with nidi of lacunar resorbtion of bone girders. There are small haemorrhages and grains of haemosiderin. What is the diagnosis? Giant-cell epulis Amyloblastoma Fibrous osteodysplasia Osteosarcoma @Osteoblastoclastoma # 46 4-year-old child presented with a flat red color knot on his neck skin, which turns pale at pressing by glass the knot. What is the most probable diagnosis? @Hemangioma Pigmented nevus Melanoma Leiomyoma Lymphangioma # 47 A 14-year-old healthy girl has a 0.3-cm reddish, slightly raised nodule on the skin of the upper part of her chest found on a routine physical examination. She states that this lesion has been present for years and has not appreciably changed in size or color. Which of the following neoplasms is this nodule most likely to be: @Hemangioma Melanoma Wilms tumor Lymphoma Glioma # 48 A very painful lesion found under the nail of the second finger of the hand is most likely which one of the following lesion of blood vessels or lymphatics? Kaposi’s sarcoma @Capillary hemangioma Glomus tumor angiosarcoma Cystic hydroma # 49 Microscopically the tumour of the upper lip is built of multiple small chink-like cavities, the walls of which are covered with endothelium and filled with liquid part of blood and its clots. Make a diagnosis. Glomus-angioma Venous hemangioma Cavernous hemangioma Haemangiopericytoma @Capillary hemangioma # 50 Microscopically: tumour of upper lip, made of numerous slot-like cavities, walls of which is made of flatted endothelia. These cavities are filled with thin blood and clots. Name the diagnosis. @Capillary haemangioma Venous haemangioma Cavernous hemangioma Hemangiopericytoma Glomus-angioma # 51 A 20-year-old man has had a slowly growing reddish nodule on his upper lip. He finally decides to have a surgeon remove it. Microscopically the nodule is composed of benign varying sized tiny blood vessels. What is the most likely diagnosis? @Capillary hemangioma. Venous hemangioma. Cavernous hemangioma. Hemangiopericytoma. Glomus-angioma. # 52 A 17-year-old patient was diagnosed (at the operation) a tumour (4,5 x 5,0 x 3,5cm) on the lower surface of the liver. It has sub serous localization and murrey color. On the incision it is presented by cavities with volumes of blood and thick walls of connective tissue that are covered with one stratum of endothelium. Make a previous diagnosis. @Cavernous haematoma Capillary hemangioma Haemangiopericytoma Haemangioendothelioma Lymphangioma # 53 During surgery in a 17-year-old patient it was revealed the tumour of 4,5х5,0х3,5 sm in size on the lower surface of the liver with subserose localization, of dark-red color. On the section tumour has cavities with marked amount of blood. What is preliminary diagnosis? Capillar hemangioma Hemangiopericytoma Lymphangioma Hemangioendothelioma @Cavernous hemangioma |