Патан База Тестов. Патанатомія тесты база. Патанатомія. Тести
 Скачать 0.71 Mb.
|
|
Is the neoplasm invading the margin of resection? What is the size of the neoplasm? @What is the degree of atypia and pleomorphism of the neoplastic cells? How much inflammation is present in the neoplasm? Is the neoplasm primary or metastatic? # 20 A surgical pathology report indicates that a certain neoplasm is graded as grade I on a scale of I to IV. Clinically, this neoplasm is found to be stage I. These findings imply that this neoplasm: Is unlikely to be malignant Has probably arisen from epithelium May spread via lymphatics Has an in situ component @Is well-differentiated and localized # 21 Preventive examination of a patient revealed an enlarged lymph node of metastatic origin on the medial wall of the left axillary crease. Specify the most likely localization of the primary tumour: Submandibular salivary gland Stomach Lung Thyroid gland @Mammary gland # 22 A 55-year-old man dies after a year-long illness. At autopsy the liver contains multiple tumor masses from 2 to 5 cm in size that are mostly firm and tan and that grossly exhibit umbilication with central necrosis. Which of the following statements would best characterize the significance of such an appearance? There is multicentric origin of a benign neoplasm. The neoplasm has a high grade. @The primary neoplasm is in the stomach. A carcinogen was the underlying cause for the neoplasm. The neoplasm has an advanced stage. # 23 A 39-year-old woman presented in oncology with a stomach cancer. Physical investigation revealed metastatic tumors in ovaries (Krukenberg tumors). What is most likely pattern of spread in that case? @Lymphatic retrograde Lymphatic orthograde Gematogenous Implantation Along epithelium-lined surfaces # 24 A 60-year-old man who has a 90-pack year history of cigarette smoking has had a chronic cough for years. He has recently begun to lose weight. He has a chest radiograph that reveals a right hilar mass. A sputum cytology shows atypical, hyperchromatic squamous cells. What is the most common initial pathway of spread of this lesion: Bloodstream Pleural cavity Contiguous spread to chest wall @Lymphatics Bronchi # 25 A post-mortem of a 48-year-old woman with a history of an operated stomach tumour in the past revealed markedly enlarged, dense, whitish color ovary. Histological investigation of the ovarian tissue showedutterly atypical epithelial cells, placed among layers and cords of a connective tissue. What if the most likely disease? @Krukenberg's carcinoma of ovary Serous cystadenocarcinoma Pseudomucinous cystcarcinoma Malignant thecoma Malignant granular cell tumor # 26 A physical examination of a 42-year-old patient revealed enlarged supraclavicular lymph nodes. A histological investigation of a lymph node biopsy showed the metastasis of a signet-ring cancer. Choose the most probable localization of a primary tumour. @Carcinoma of stomach Cancer of esophagus Cancer of thyroid gland Carcinoma of lungs Carcinoma of uterine cervix # 27 A post-mortem of a 59-year-old man, who died of a lung cancer, revealed plural metastases. What kind from the listed below metastases it is possible to regard as implantation (contact) one according to a mechanism of development? @Multiple tumorous nodules of pleura Metastasis in prebronchial, paratracheal lymphatic knots Metastasis in a brain Metastases in an adrenal gland Invasion of tumor from bronchus in an esophagus # 28 A 60-year-old man who has a 90 pack year history of cigarette smoking has had a chronic cough for the past 10 years. He has begun to lose weight during the past year. No abnormal findings are noted on physical examination. He has a chest radiograph that reveals a right hilar mass. A sputum cytology shows atypical, hyperchromatic squamous cells. What is the most common initial pathway of spread of this lesion? Bloodstream Pleural cavity @Contiguous spread to chest wall Lymphatics Bronchi # 29 A mass lesion in the right upper lobe of lung found by chest radiograph is removed by wedge resection and sent to Surgical Pathology, where a neoplasm is diagnosed. Findings that will be important for determining further therapy and prognosis include all of the following EXCEPT: Is the neoplasm invading the margin of resection? What is the size of the neoplasm? What is the degree of atypia and pleornorphism of the neoplastic cells? @How much inflammation is present in the neoplasm? Is the neoplasm primary or metastatic? # 30 An autopsy of a 50-year-old man, who died of cancer intoxication, revealed the thickening of a stomach's wall to 1, 2 cm. The mucosa was fixed, with ill-defined gastric folds. On a cut view a tissue was homogeneous, whitish with chondroid density. For what macroscopical form of a tumour the described changes are characteristic? @Infiltrate Node Ulcer Ulcerous-infiltration Cyst # 31 During an autopsy of man, who died of cancer intoxication: gaster wall is thickened (1,2cm), mucous membrane is immovable and has no folds. On incision is homogenous, white coloured, has consistency of cartilage. What morphologic kind of tumour is this? @Infiltration Node Ulcer Ulcer-infiltrative Cyst # 32 A 45 year old woman has a chest x-ray taken and is found to have a peripheral "coin lesion" that is a rounded, circumscribed 2.5 cm mass in the right mid-lung field. She has no chest pain, cough, or fever. The biologic characteristic that best distinguishes this lesion as a neoplasm, rather than a granuloma is: Recurrence following excision Rapid increase in size Sensitivity to radiation or chemotherapy @Uncontrolled (autonomous) growth Necrosis # 33 A 45-year old male with a family history of a gastric cancer inquires about screening. A gastroscopic examination of a patient revealed a pedunculated tumor mass 1.5 cm in diameter in the area of the lesser curvature of stomach. What kind of growth does the tumor have? @Exophytic Expansive Infiltrating Appositional Endophytic # 34 Pre-malignant conditions include all of the following conditions EXCEPT: Endometrial hyperplasia following prolonged estrogen therapy Chronic alcoholism leading to micronodular cirrhosis of the liver Cervical squamous dysplasia Chronic ulcerative colitis @Multiple leiomyomas of the uterine myometrium # 35 A 40-year-old woman has had a feeling of abdominal discomfort for the past 8 months. On pelvic examination, there is a right adnexal mass. An abdominal CT scan demonstrates a 7 cm cystic mass involving the right ovary with small areas of calcification. The uterus is normal in size. The right fallopian tube and ovary are removed surgically. Grossly, the mass on sectioning is filled with abundant hair and sebum. Microscopically, the mass has glandular spaces lined by columnar epithelium, squamous epithelium with hair follicles, cartilage, and dense connective tissue. Which of the following statements regarding this type of neoplasm is most appropriate? A sarcomatous element is usually present A human papillomavirus infection preceded development of this mass Metastases are unlikely to be present @Tissues resembling those from an embryo can usually be seen Such a mass is often seen to arise in the testis # 36 A 40-year-old woman has had a feeling of abdominal discomfort for the past 8 months. On pelvic examination, there is the right adnexal mass. Abdominal CT scan demonstrates a 7 cm cystic mass involving the right ovary with small areas of calcification. The uterus is normal in size. The right fallopian tube and ovary have been removed surgically. Grossly, the mass on sectioning is filled with abundant hair and sebum. Microscopically, the mass has glandular spaces lined by columnar epithelium, squamous epithelium with hair follicles, cartilage, and dense connective tissue. What type of tumour is it? Melanoma Squamous cell carcinoma of ovary Metastase of cervical carcinoma @Teratoma Sarcoma of ovary # 37 A 32-year-old woman has noted dull pelvic pain for the last two months. On physical examination there is a mass palpated in the right lower quadrant. An abdominal ultrasound reveals an 8 cm mass involving the right ovary. The mass is surgically excised. On gross inspection, the surface of the mass is smooth, is not adherent to surrounding pelvic structure, and is cystic and filled with hair on sectioning. On microscopic examination there is squamous epithelium, tall columnar glandular epithelium, cartilage, and fibrous connective tissue. Which of the following neoplasms is she most likely to have? @Teratoma Choristoma Hamartoma Myxoma Mesothelioma # 38 An epidemiologic study is performed involving patients with long-standing Epstein-Barr virus infection. It is observed that these patients have an increased risk for development of malignant neoplasms in adulthood. Which of the following neoplasms is most likely to be found in these patients? @Nasopharyngeal carcinoma Kaposi sarcoma Small cell anaplastic carcinoma of lung Osteosarcoma Endometrial carcinoma # 39 A 34-year-old woman presented with a hoarseness of a voice. A laryngoscopy revealed a tumour of a larynx. The neoplasm had a grey-white color and papillary surface. Microscopical investigation showed a new growth of a connecting tissue, covered by a stratified epithelium with the marked keratinization. Cellular atypia was absent. Most likely the tumor is: @Papilloma Fibroma Polyp Angioma Angiofibroma # 40 A man was performed a removal of a skin neoplasm, node with papillary surface that looks like cauliflower cabbage, of thick consistency. Microscopically tumour consists of numerous papillae. Parenchyma is made of cover epithelia with multiple layers. Polarity of cells, stratification, and basal membrane integrity are not changed. Stroma of the tumour is situated in its centre. Name the diagnosis. @Papilloma Fibroma Adenoma Fibroadenoma Cystadenoma # 41 A 15-year-old boy is found to have a small, dense, nodule at his right forearm skin. Grossly it had a papillary surface, which looked like a cauliflower. Microscopically, the tumor consists of many papillae. Parenchyma formed of integumentary epithelium with an increased amount of layers. The polarity of epithelial cells, their stratification and membrane wholeness are preserved. A connective tissue forms a stroma within a center of papillae. What is the most likely diagnosis? @Papilloma. Fibroma. Adenoma. Fibroadenoma. Cystadenoma. # 42 A 50-year-old female is found to have a urinary bladder neoplasm. Biopsy investigation revealed that tumor consists of thin, branching out papillae, covered with few layers of transitional cell epithelium. What is the most likely diagnose? @Papilloma Basal cell Transitional cell carcinoma Squamous cell carcinoma Fibroadenoma # 43 A new growth of the skin of solid consistency, that looks like a nodule with papillar surface and reminds cauliflower was removed. Microscopically the tumour consists of many papillae. Parenchyma is formed of integumentary epithelium with an increased amount of strata. The polarity of cells, stratification and the intact membrane are saved in the epithelium. The tumour stroma is located in the center of papillae. What is the most possible diagnosis? @Papilloma Fibroma Adenoma Fibroadenoma Cystadenoma # 44 A previously healthy 66-year-old man has been feeling tired for 5 months. He goes to his physician, who performs a complete physical examination, including stool guaiac, which is positive. A colonoscopy is performed, and a large, sessile 4.5 cm mass with surface ulceration is found in the cecum. A biopsy of this mass microscopically shows irregular glands with crowded, tall columnar cells having marked nuclear hyperchromatism. Which of the following statements about his condition is most accurate? @His relatives have hereditary adenomatous polyposis There is lack of apoptosis from a faulty Bcl-2 gene A p53 mutation is present in the neoplastic cells He has hereditary non-polyposis colon cancer He has inherited a faulty Rb gene from one parent # 45 A 23-year-old woman presents with a 0.4 cm nodule within the skin on the left side of her neck. The clinical removes the lesion and sends it to the pathology lab, calling it a “sebaceous cyst”. Histologic sections reveal a cystic structure is the dermis that is filled with keratin and lined by a stratified squamous epithelium, which has a granular cell layer. This cyst is not ruptured, no adnexal structures are seen within the wall of the cyst, and no atypia is present. Which of the following is the most likely diagnosis? Acrochordon Cystis hygroma @Epithelial inclusion cyst Intradermal nevus Pilar cyst # 46 A 38-year-old woman was diagnosed a tumour in the parotid gland. It consists of separate nodules that are separated by strata of connective tissue. Pathohistologically: the cells are of epidermoid type and form solid structures. Mucous-productive cells form tension bars that cover cavities with mucous. The third element of the tumour is small cells with hyperchromic nucleus. What tumour is meant? Papillary cystadenoma Acinocellular tumour @Mucoepidermoid tumour Adenolymphoma Adenocystic carcinoma # 47 A healthy 22-year-old woman undergoes a routine physical examination. A discrete, firm, rubbery, movable mass is found in the left breast. She has no axillary lymphadenopathy. The skin overlying the breast and the nipple appear normal. Which of the following neoplasms is most likely to be present? @Fibroadenoma Leiomyoma Malignant lymphoma Intraductal carcinoma Lipoma # 48 A physical investigation of a 25-year-old-woman revealed in her breast a dense node 1,0 cm in diameter. A biopsy research showed encapsulated growth of a connective tissue round a basal membrane of a mammary gland ducts. Glandular elements had different diameter, did not form lobes. What is the most likely diagnosis? @Fibroadenama Fibroma Metastasis of a cancer Adenoma Fibrous cancer # 49 A 45-year-old woman presented to oncology with a breast tumor. A biopsy revealed a tissue atypia with stromal predominance over neoplastic parenchyma. Breast ducts and ductules were variable, they had one or two layered epithelium without atypical mitotic activity. The intralobular stroma was dence. What is the most likely diagnosis? @Fibroadenoma Papilloma Non-invasive carcinoma Invasive carcinoma Mastitis # 50 The intraoperational biopsy of mammal gland has revealed the signs of atypical tissue with disorder of parenchyma stroma proportion with domination of the last, gland structures of the different size and shape, lined with single-layer proliferative epithelium. What is the most appropriate diagnosis? Mastitis Papilloma Noninfiltrative cancer @Fibroadenoma Infiltrative cancer # 51 A histological investigation of the biopsy from cervix uteri of a 45-year-old woman revealed signs of cellular atypia with intact basal membrane. What is the most likely diagnosis? @Carcinoma in situ Erosion Adenocarcinoma Papilloma Endometriosis # 52 A 57-year-old postmenopausal woman is found to have a chronic nonhealing lesion at her portio vaginalis uteri.A biopsy was taken form this area. A histological examination of the biopsy material revealed a cellular atypism within epithelial layer, but basic membrane was unchanged. What is the most likely diagnosis? @Carcinoma in situ. Erosion. Adenocarcinoma. Papilloma. Endometriosis. # 53 A 41-year-old woman has noted a foul-smelling vaginal discharge for 3 weeks. On physical examination there is an exophytic 3 cm mass involving the ectocervix. Pap smear testing is performed; she has never had a previous Pap smear. Cytologic changes are present on this Pap smear that are consistent with squamous cell carcinoma. She is found to have a positive serologic test for syphilis. Her serum glucose is 157 mg/dL She has been a commercial sex worker in the past. Which of the following is the most likely risk factor for her cervical carcinoma? @Human papillomavirus infection Diabetes mellitus, type II Heavy cigarette smoking Pelvic inflammatory disease Previous cancer chemotherapy # 54 At the histological examination of a bioptic material from a vaginalis part of the cervix of the uterus, that was taken from a 47-year old woman, the attributes of the cell atypism, the basal membrane – without changes were detected. This part of the uterus didn’t heal up for a long time. Make a diagnosis. Erosion @Carcinoma in situ Adenocarcinoma Papilloma Endometriosis # 55 A 62-year-old man has complained of pain on urination for the past week. He is afebrile. On cystoscopy, a slightly erythematous 1 cm diameter area is seen on the bladder mucosa. This area is biopsied and on microscopic examination shows cells with marked hyperchromatism and increased nuclear/cytoplasmic ratio involving the full thickness of the epithelium. However, these changes are confined to the epithelium above the basement membrane. Which of the following terms best describes these biopsy findings? @Carcinoma in situ Metaplasia Minimal dysplasia Microinvasion Hyperplasia # 56 A 67-year-old man present with a slowly growing lesion that involves the lower portion of his left lower eyelid. You examine the lesion and find it to be a pearly papule with raised margins and a central ulcer (rodent ulcer). Which on the following histologic features would most likely be seen when examining histologic section from this lesion? Reactive epidermal cells surrounding a central superficial ulcer @Infiltrating groups of basaloid cells with peritumoral clefting Infiltrating groups of eosinophilic cells with keratin formation Dermal aggregated of small cells histologically similar to oat cell carcinoma An in situ lesion with full-thickness epidermal atypia # 57 A 48-year-old man has presented to his physician a plaque-like formation on a neck. Histological investigation of a skin biopsy revealed tumorous cells located as nests, having round and oval form with narrow rim of basophilic cytoplasm. They reminded cells of a skin basal layer. Specify the tumor name. @ Basal cell epithelioma Epidermal cancer Hidroadenoma Trichoepithelioma Syringadenoma # 58 A 45 year old man consulted a doctor about a plaque-like formation on his neck. Histological examination of a skin bioptate revealed clusters of round and oval tumour cells with a narrow border of basophilic cytoplasm resembling of cells of basal epidermal layer. What tumour is it? Epidermal cancer Syringoadenoma Trichoepithelioma @Basal cell carcinoma Hydroadenoma # 59 |