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    Стивен_Гандри_Парадокс_долголетия_Как_оставаться_молодым_до_глуб. Стивен Гандри Парадокс долголетия. Как оставаться молодым до глубокой старостиОткрытия века доктор Гандри


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    Глава 1: Ваша судьба в руках древних генов
    1. Dariush Mozaffarian, Tao Hao, Eric B. Rimm, и другие., «Changes in Diet and Lifestyle and Long-Term Weight Gain in
    Women and Men,» New England Journal of Medicine 364, no. 25 (June 2011): 2392–404, Доступ по ссылке: https://www.nejm.org/doi/full/10.1056 /NEJMoa1014296?query=TOC&smid=nytcore-ios-share#t=articleTop.
    2. Daphna Rothschild, Omer Weissbrod, Elad Barkan, и другие., «Environment Dominates over Host Genetics in Shaping
    Human Gut Microbiota,» Nature 555 (March 2018): 210–15, Доступ по ссылке: https://www.nature.com/articles/nature25973.
    3. Gaorui Bian, Gregory B. Gloor, Aihua Gong, и другие., «The Gut Microbiota of Healthy Aged Chinese Is Similar to
    That of the Healthy Young,» mSphere 2, no. 5 (September – October 2017): Доступ по ссылке: https://msphere.asm.org/content/msph/2/5/e00327-17.full.pdf.
    4. Elena Biagi, Claudio Franceschi, Simone Rampelli, и другие., «Gut Microbiota and Extreme Longevity,» Current
    Biology: CB 26, no. 11 (May 2016): Доступ по ссылке: https://www.researchgate.net/publication/303027047_Gut_Microbiota_and_Extreme_Longevity.
    5. Adolfo Sanchez-Blanco, Alberto Rodríguez-Matellán, Ana González-Paramás, и другие., «Dietary and Microbiome
    Factors Determine Longevity in Caenorhabditis elegans,» Aging 8, no. 7 (July 2016): 1513–30, Доступ по ссылке: https://
    www.ncbi.nlm.nih.gov/pmc/articles /PMC4993345/.
    6. University of Alabama at Birmingham, «Scientists Reverse Aging-Associated Skin Wrinkles and Hair Loss in a Mouse
    Model: A Gene Mutation Causes Wrinkled Skin and Hair Loss; Turning Off That Mutation Restores the Mouse to Normal
    Appearance,» ScienceDaily, July 20, 2018, Доступ по ссылке: https://www.sciencedaily.com/releases/2018/07/180720112808.htm.
    7. Jan Gruber and Brian K. Kennedy, «Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondra,» Cell
    169, no. 7 (June 2017): 1168–69, http://www.cell.com/cell/fulltext/S0092-8674(17)30641-4.
    8. Bing Han, Pryia Sivaramakrishnan, Chih-Chun J. Lin, и другие., «Microbial Genetic Composition Tunes Host
    Longevity,» Cell 169, no. 7 (June 2017): 1249–62, Доступ по ссылке: https://www.sciencedirect.com/science/article/pii/S009286741730627X.
    9. Elaine Patterson, John F. Cryan, Gerald F. Fitzgerald, и другие., «Gut Microbiota, the Pharmabiotics They Produce and
    Host Health,» Proceedings of the Nutrition Society 73, no. 4 (November 2014): 477–89, Доступ по ссылке: https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/gut-microbiota-the-pharmabiotics- they-produce-and-host-health/4961D7293641D4FC3255468A22C7FF66.
    10. Jin Li, Shaoqiang Lin, Paul M. Vanhoutte, и другие., «Akkermansia Muciniphila Protects Against Atherosclerosis by
    Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe Mice,» Circulation 133, no. 24 (April 2016): 2434–46,
    Доступ по ссылке: https://www.ahajournals.org/doi/full/10.1161/circulationaha.115.019645.
    11. Ming Fu, Weihua Zhang, Lingyun Wu, и другие., «Hydrogen Sulfide (H2S) Metabolism in Mitochondria and Its
    Regulatory Role in Energy Production,» Proceedings of the National Academy of Sciences of the United States of America
    109, no. 8 (February 2012): 2943–48, http://www.pnas.org/content/109/8/2943.

    12. Tewodros Debebe, Elena Biagi, Matteo Soverini, и другие., «Unraveling the Gut Microbiome of the Long-Lived
    Naked Mole-Rat,» Scientific Reports 7 (August 2017): Доступ по ссылке: https://www.nature.com/articles/s41598-017-
    10287-0.
    13. M. Bernstein, «Bifidobacteria lpngum, Roseburia, F. prausnitzii (and Akkermansia) Made Us Human (None of These
    Eat Raw Potato Starch) (Part 1) NSFW,» Animal Pharm, November 9, 2014, http://drbganimalpharm.blogspot.com/2014/11/bifidobacteria-longum-roseburia-f.html.
    14. Anna Azvolinsky, «Primates, Gut Microbes Evolved Together,» The Scientist, July 21, 2016, http://mobile.the- scientist.com/article/46603/primates-gut-microbes-evolved-together.
    15. Yolanda Sanz, «Effects of a Gluten-Free Diet on Gut Microbiota and Immune Function in Healthy Adult Humans,» Gut
    Microbes 1, no. 3 (March 2010): 135–37, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023594/.
    16. David R. Montgomery and Anne Biklé, The Hidden Half of Nature: The Microbial Roots of Life and Health (New
    York: W. W. Norton, 2016), cited a study by Lee S. Gross, Li Li, Earl S. Ford, and Simin Liu, «Increased Consumption of
    Refined Carbohydrates and the Epidemic of Type 2 Diabetes in the United States: An Ecologic Assessment,» American
    Journal of Clinical Nutrition 79 (2004): 774–79, Доступ по ссылке: https://cwru.pure.elsevier.com/en/publications/increased-consumption-of-refined-carbohydrates-and-the-epidemic-o-3.
    17. University of Colorado at Boulder, «Personal Care Products Contribute to a Pollution ‘Rush Hour’: Emissions from
    Products Such as Shampoo and Perfume Are Comparable to the Emissions from Auto Exhaust,» ScienceDaily, April 30,
    2018, Доступ по ссылке: https://www.sciencedaily.com/releases/2018/04/180430131828.htm.
    18. Roddy Scheer and Doug Moss, «Dirt Poor: Have Fruits and Vegetables Become Less Nutritious?» Scientific American
    (no date), http://www.scientificamerican.com/article/soil-depletion-and-nutrition-loss/.
    19. Martin J. Blaser, Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues (New York: Henry
    Holt, 2014).
    20. Peter J. Turnbaugh, Micah Hamady, Tanya Yatsunenko, и другие., «A Core Gut Microbiome in Obese and Lean
    Twins,» Nature 457, no. 7228 (January 22, 2009): 480–84, Доступ по ссылке: https://www.nature.com/articles/nature07540.
    21. John J. Gildea, David A. Roberts, and Zachary Bush, «Protective Effects of Lignite Extract Supplement on Intestinal
    Barrier Functions in Glyphosate-Mediated Tight Junction Injury,» Journal of Clinical Nutrition and Diabetics 3, no. 1
    (January 2017): 1–6, http://clinical-nutrition.imedpub.com/abstract/protective-effects-of-lignite-extract-supplement-on- intestinal-barrier-function-in-glyphosatemediated-tight-junction-injury-18161.html.
    22. Shannon Van Hoesen, «World Health Organization Labels Glyphosate Probable Carcinogen,» EWG, March 2015, http://www.ewg.org/release/world-health-organization-labels-glyphosate-probable-carcinogen.
    23. S. Parvez, R. R. Gerona, C. Proctor, и другие., «Glyphosate Exposure in Pregnancy and Shortened Gestational Length:
    A Prospective Indiana Birth Cohort Study,» Environmental Health 17, no. 1 (2018): 23, Доступ по ссылке: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-018-0367-0.
    24. A. Gore, V. Chappell, S. Fenton, и другие., «EDC-2: The Endocrine Society’s Second Scientific Statement on
    Endocrine-Disrupting Chemicals,» Endocrine Reviews 36, no. 6, (December 2015): E1–E150, http://www.ncbi.nlm.nih.gov/pubmed/26544531.
    25. Pheruza Tarapore, Jun Ying, Bin Ouyang, и другие., PLOS One 9, no. 3 (March 2014): 1–11, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090332.
    26. Jan Gruber and Brian K. Kennedy, «Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria,»
    Cell 169, no. 7 (June 2017): 1168–69, http://www.cell.com/cell/fulltext/S0092-8674(17)30641-4.

    27. Yaw A. Nyame, Adam B. Murphy, Diana K. Bowen, и другие., «Assocations Between Serum Vitamin D and Adverse
    Pathology in Men Undergoing Radical Prostatectomy,» Journal of Clinical Oncology 34, no. 12 (April 2016): 1345–50, http://ascopubs.org/doi/10.1200/JCO.2015.65.1463.
    28. M. B. Abou-Donia, E. M. El-Masry, A. A. Abdel-Rahman, и другие., «Splenda Alters Gut Microflora and Increases
    Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats,» Journal of Toxicology Environmental Health 71, no. 21
    (2008): 1415–29, Доступ по ссылке: https://www.ncbi.nlm.nih.gov/m/pubmed/18800291/.
    Глава 2: Защита и оборона
    1. Claudio Franceschi and Judith Campisi. «Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-
    Associated Diseases,» Journals of Gerontology: Series A 69, no. 1 (June 2014): S4–S5, Доступ по ссылке: https://www.ncbi.nlm.nih.gov/m/pubmed/24833586/.
    2. University of Pittsburgh Medical Center, «Difference Between Small and Large Intestine,» Children’s Hospital of
    Pittsburgh Educational Resources, 2018, http://www.chp.edu/our-services/transplant/intestine/education/about-small-large- intestines.
    3. Francie Diep, «Human Gut Has the Surface Area of a Studio Apartment,» Popular Science, April 23, 2014, http://www.popsci.com/article/science/human-gut-has-surface-area-studio-apartment.
    4. «Digestive 6,» Quizlet, 2018, Доступ по ссылке: https://quizlet.com/11845442/digestive-6-flash-cards/.
    5. Franceschi, and Campisi, «Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated
    Diseases.»
    6. S. Manfredo Vieira, Michael Hiltensperger, V. Kumar, и другие., «Translocation of a Gut Pathobiont Drives
    Autoimmunity in Mice and Humans,» Science 359, no. 6380 (March 9, 2018): 1156–61, http://science.sciencemag.org/content/359/6380/1156.
    7. Steven R. Gundry, «Abstract P238: Remission/Cure of Autoimmune Diseases by a Lectin Limite Diet Supplemented with Probiotics, Prebiotics, and Polyphenols,» Circulation 137, no. 1, (June 2018): 238, Доступ по ссылке: https://www.ahajournals.org/doi/abs/10.1161/circ.137.suppl_1.p238.
    8. Jawahar L. Mehta, Tom G. P. Saldeen, and Kenneth Rand, «Interactive Role of Infection, Inflammation and Traditional
    Risk Factors in Atherosclerosis and Coronary Artery Disease,» Journal of the American College of Cardiology 31, no. 6
    (May 1998): 1217–25, Доступ по ссылке: https://www.sciencedirect.com/science/article/pii/S073510979800093X.
    9. Robert J. F. Laheij, Miriam C. J. M. Sturkenboom, Robert-Jan Hassing, и другие., «Risk of Community-Acquired
    Pneumonia and Use of Gastric Acid – Suppressive Drugs,» Journal of the American Medical Association 292, no. 16
    (October 2004): 1955–60, http://jama.jamanetwork.com/article.aspx?articleid=199672.
    10. Jan Bures, Jiri Cyrany, Darina Kohoutová, и другие., «Small Intestinal Bacterial Overgrowth Syndrome,» World
    Journal of Gastroenterology 16, no. 24 (June 2010): 2978–90, Доступ по ссылке: https://www.researchgate.net/publication/44696633_Small_intestinal_bacterial_overgrowth_syndrome.
    11. Medical College of Georgia at Augusta University, «Drinking Baking Soda Could Be an Inexpensive, Safe Way to
    Combat Autoimmune Disease,» ScienceDaily, April 25, 2018, Доступ по ссылке: https://www.sciencedaily.com/releases/2018/04/180425093745.htm.
    12. S. Y. Tai, C. Chien, D. Wu, и другие., «Risk of Dementia from Proton Pump Inhibitor Use in Asian Population: A
    Nationwide Cohort Study in Taiwan,» PLOS One 12, no. 2 (February 2017): Доступ по ссылке: https://www.ncbi.nlm.nih.gov/pubmed/28199356.
    13. Dennis Thompson, «Popular Heartburn Drugs Linked to Risk of Dementia,» USA Today, February 16, 2016, http://www.usatoday.com/story/news/health/2016/02/16/popular-heartburn-drugs-linked-to-risk-of-dementia/80442834/.

    14 Benjamin Lazarus, Yuan Chen, Francis P. Wilson, и другие., «Proton Pump Inhibitor Use and Risk of Chronic Kidney
    Disease,» Journal of the American Medical Association 176, no. 2 (February 2016): 238–46, Доступ по ссылке: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772730/.
    15. U. Engel, D. Breborowicz, T. Bøg-Hansen, и другие., «Lectin Staining of Renal Tubules in Normal Kidney,» Applied
    Mathematics and Information Sciences 105, no. 1 (January 1997): 31–34, http://www.ncbi.nlm.nih.gov/m/pubmed/9063498/.
    16. George Institute for Global Health, «Diabetes Raises Risk of Cancer, with Women at Even Greater Likelihood, a Major
    New Study Has Found,» ScienceDaily, July 19, 2018, Доступ по ссылке: Доступ по ссылке: https://www.sciencedaily.com/releases/2018/07/180719195650.htm.
    17. «Statistics About Diabetes,» American Diabetes Association, http://www.diabetes.org/diabetes-basics/statistics/.
    18. IOS Press, «Insulin Resistance Under-Diagnosed in Non-Diabetics with Parkinson’s Disease,» ScienceDaily, August 2,
    2018, Доступ по ссылке: https://www.sciencedaily.com/release s/2018/08/180802151525.htm.
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    20. K. J. Mukamal, S. E. Chiuve, and E. B. Rimm, «Alcohol Consumption and Risk for Coronary Heart Disease in Men with Healthy Lifestyles,» Archives of Internal Medicine 166, no. 19 (October 2006): 2145–50, Доступ по ссылке: https://
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    21. Centre National de la Recherche Scientifique, «Eating Less Enables Lemurs to Live Longer,» ScienceDaily, April 5,
    2018, Доступ по ссылке: https://www.sciencedaily.com/releases/2018/04/180405093241.htm.
    22. Sara Gelino, Jessica T. Chang, Caroline Kumsta, и другие., «Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction,» PLOS Genetics 12, no. 8 (July 2016): http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006135.
    23. Louise E. Tailford, Emmanuelle H. Crost, Devon Kavanaugh, и другие., «Mucin Glycan Foraging in the Human Gut
    Microbiome,» Frontiers in Genetics 6, no. 8 (March 2015): Доступ по ссылке: https://www.frontiersin.org/articles/10.3389/fgene.2015.00081/full.
    24. Jin Li, Shaoqiang Lin, Paul M. Vanhoutte, и другие., «Akkermansia Muciniphila Protects Against Atherosclerosis by
    Preventing Metabolic Endotoxemia-Induced Inflamation in Apoe Mice,» Circulation 133, no. 24 (June 2016): 2434–46,
    Доступ по ссылке: https://www.ncbi.nlm.nih.gov/m/pubmed/27143680/?i=4&from=/23671105/related.
    25 Moran Yassour, Mi Young Lim, Hyun Sun Yun, и другие., «Sub-Clinical Detection of Gut Microbial Biomakers of
    Obesity and Type 2 Diabetes,» Genome Medicine 8, no. 16 (February 2016): Доступ по ссылке: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0271-6.
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    27. J. de la Cuesta-Zuluaga, N. T. Mueller, V. Corrales-Agudelo, и другие., «Metformin Is Associated with Higher Relative
    Abundance of Mucin-Degrading Akkermansia Muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut,» Diabetes Care 40, no. 1 (January 2017): Доступ по ссылке: https://www.ncbi.nlm.nih.gov/pubmed/27999002.
    28. Ibid.
    29. M. Carmen Collado, Muriel Derrien, Erika Isolauri, и другие., «Intestinal Integrity and Akkermansia muciniphila, a
    Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly,» Applied and
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    30. X. Gao, Q. Xie, P. Kong, и другие., «Polyphenol- and Caffeine-Rich Postfermented Puerh Tea Improves Diet-Induced
    Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice,» Infection and Immunity 86, no. 1 (January 2018):
    Доступ по ссылке: https://www.ncbi.nlm.nih.gov/m/pubmed/29061705/?i=4&from=/25080446/related.
    31. Laura García-Prat, Marta Martínez-Vicente, Eusebio Perdiguero, и другие., «Autophagy Maintains Stemness by
    Preventing Senescence,» Nature 529, no. 1 (January 2016): 37–57, http://twin.sci-hub.tw/6695/3bb2aef883e8dde32b63cc52a0f897cc/garcaprat 2016.pdf.
    32. University of Southern California, «Fasting Triggers Stem Cell Regeneration of Damaged, Old Immune System,»
    ScienceDaily, June 5, 2014, Доступ по ссылке: https://www.science daily.com/releases/2014/06/140605141507.htm.
    33. S. Melanie Lee, Gregory P. Donaldson, Zbigniew Mikulski, и другие., «Bacterial Colonization Factors Control
    Specificity and Stability of the Gut Microbiota,» Nature 501, no. 7467 (September 19, 2013): 426–29, Доступ по ссылке: https://www.researchgate.net/profile/Klaus_Ley/publication/255975522_Bacterial_colonization_factors_control_specificity
    _and_stability_of_the_gut_microbiota/links/0f31753cd1efbd6ade000000/Bacterial-colonization-factors-control-specificity- and-stability-of-the-gut-microbiota.pdf.
    34. Eugene Kang, Mitra Yousefi, and Samantha Gruenheid, «R-Spondins Are Expressed by the Intestinal Stroma and Are
    Differently Regulated duringCitrobactoer rodentiumand DSS-Induced Colitis in Mice,» PLOS One 11, no. 4, (April 2016): http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152859.
    35. Karla A. Mark, Kathleen J. Dumas, Dipa Bhaumik, и другие., «Vitamin D Promotes Protein Homeostasis and
    Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1,» Cell Reports 17, no. 5 (October 2016): 1227–
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    36. Javeria Saleem, Rubeena Zakar, Muhammad Z. Zakar, и другие., «High-Dose Vitamin D3 in the Treatment of Severe
    Acute Malnutrition: A Multicenter Double-Blind Randomized Controlled Trial,» American Journal of Clinical Nutrition
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    37. I. Flores, A. Canela, E. Vera, и другие., «The Longest Telomeres: A General Signature of Adult Stem Cell
    Compartments,» Genes and Development 22, no. 5 (March 2008): 654–67, Доступ по ссылке: https://www.ncbi.nlm.nih.gov/m/pubmed/18283121/.
    38. J. Brent Richards, Ana M. Valdes, Jeffrey P. Gardner, и другие., «Higher Serum Vitamin D Concentrations Are
    Associated with Longer Leukocyte Telomere Length in Women,» American Journal of Clinical Nutrition 86, no. 5
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    40. Samuel A. Smits, Jeff Leach, Erica D. Sonnenburg, и другие., Seasonal Cycling in the Gut Microbiome of the Hadza
    Hunter-Gatherers of Tanzania,» Science 357, no. 6353 (August 2017): 802–6, http://science.sciencemag.org/content/357/6353/802.
    41. Columbia University’s Mailman School of Public Health, «What the Gorilla Microbiome Tells Us about Evolution and
    Human Health: Researchers Find the Microbiomesof Wild Gorillas Shift Seasonally When Once a Year They Switch from
    Eating Fibrous Leaves to Eating Fruit,» ScienceDaily, May 3, 2018, Доступ по ссылке: https://www.sciencedaily.com/releases/2018/05/180503085553.htm.
    42. J. L. Broussard, D. A. Ehrmann, E. van Cauter, и другие., «Impaired Insulin Signaling in Human Adipocytes after
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    43. Oren Froy, «Circadian Rhythms, Aging, and Life Span in Mammals,» Physiology 26, no. 1 (August 2011): 225–35,
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    45. Maria Pina Mollica, Giuseppina Mattace Raso, Gina Cavaliere, и другие., «Butyrate Regulates Liver Mitochondrial
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